Inderal is an antihypertensive drug that has a strong antiarrhythmic and antianginal effect. Inderal contains the active ingredient Propranolol in the form of hydrochloride.
Three different dosage forms of Inderal can be used to treat cardiovascular diseases.
- Oral suspension (10 mg/ml).
- Film-coated tablets (10 mg, 20mg, 40mg, 60mg, 80 mgand 90 mg).
- Extended-release capsules (60mg, 160mg, 80 mgand 120 mg).
Inderal is intended to treat a wide range of cardiovascular diseases, including:
- angina pectoris
- myocardial infarction
- arterial hypertension
In addition, Inderal is often used for the prevention of migraine, the symptomatic treatment of pheochromocytoma, or the relief of the essential tremor.
There are several schedules of Inderaldosing, approved for the treatment of different cardiovascular diseases.
- For the therapy of angina pectoris, it is recommended to take 80-320 mg of Inderal per day;
- The effective dose of Inderal in heart failure is 180-240 mg/day;
- The daily dose of Inderal for the management of atrial fibrillation is 30 mg to 120 mg;
- For the treatment of hypertension, it is recommended to take 80 mg to 640 mg of Inderal per day.
The initial dose of Inderal for the prevention of essential tremor or migraine is 80 mg. The maximum daily dose of Inderal for the relief of headaches or tremors is 240 mg. Daily doses of Inderal are recommended to be divided into two or more uses.
Because of the risk of interaction, Inderal is not recommended to be usedtaking in combination with drugs from such medicinal groups, as:
- Antacids (including Cimetidine).
- Antidepressants (e.g., Fluoxetine).
- Antiarrhythmic drugs (such as Quinidine).
- Antiretroviral drugs (in particular Ritonavir).
A reduction in the daily dose of Inderal may be required, when patients use cytotoxic drugs (Tenioposide), antibiotics (Ciprofloxacin) or antimigraine drugs (Rizatriptan).
Frequent undesirable phenomena of Inderal are fatigue, bradycardia, bronchospasm, nausea, and discomfort in the abdomen. The results of clinical trials prove that Inderal can very rarely cause such skin adverse reactions, as:
- erythema multiforme
- Stevens-Johnson syndrome
Most of the possible side effects of Inderal are dose-depended, and quickly pass when the the dose of this antihypertensive drug is reduced.
Inderal affects the heart rate and blood pressure. Therefore, patients with certain secondary diseases are advised to follow the listed precautionsduring the course of Inderal:
- Patients with glaucoma should not use Inderal before the diagnostic procedures;
- Patients with diabetes, renal or hepatic disease may need a reduction in the daily dose of Inderal.
With a sharp completion of the Inderal course, the recurrence risk for myocardial infarction or angina increases. To avoid aggravation of these cardiovascular events, the dose of Inderal should be lowered gradually, within a few weeks.