Clomid is a non-steroidal drug with a weak estrogenic effect that is used in the treatment of female infertility. The drug causes an increase in the secretion of gonadotropins (hormones that regulate the ovariesfunction).
Clomid also stimulates the process of follicles maturation in the ovaries and promotes an increasein the concentration of the female sex hormone, estradiol.
- The drug is available in the form of 50 mg oral tablets.
- The active substance of the drug is Clomiphene citrate.
Clomid is used to treat anovulatory infertility in women. The use of the drug stimulates ovulation in infertility, which has developed as a result of secondary hypofunction of the ovaries.
Clomid showed high efficiency in the treatment of infertility in women, who suffer from:
- Amenorrhea-galactorrhea syndrome
- Polycystic Ovary Syndrome
- Post-pill and psychogenic amenorrhoea.
The drug is not recommended for patients with abnormal uterine bleeding, with liver disease and with a pituitary tumor.
Clomid is prescribedfrom the second day of the menstrual cycle. In the absence of cycle, therapy for infertility can be started at any time. For five consecutive days, woman takes one 50 mg Clomid tablet once a day before bedtime.
Patients with polycystic ovary syndrome are particularly sensitive to ovulation-promoting drugs. For this reason, these patients are prescribed no more than 25 mg of Clomid.
If ovulation does not take place after the first course, the daily dose is increased to two 50 mg Clomid tablets. The second course begins after a 30-day break. The therapeutic dose should not exceed 100 mg of Clomid per day, and the course duration is 5 days.
If the second course leads to no results, woman can repeat the course according to the second scheme in the next menstrual cycle. In anovulation, additional three courses of therapy can be heldin the same dosagesafter a 3-month break.
As of today, it is not recommended to go through the ovulation stimulation for more than 6 months. Prolonged use of Clomid increases the risk of ovarian cancer.
Clomid can be combined with medications of gonadotropic hormones. No clinically significant interaction of Clomid was established, when combined with other drugs.
If used in recommended doses, Clomid is tolerated well by patients. Side effects are usually mild and passquickly. Most often, women who use the drug, note flushes, which cease after the end of therapy.
Patients suffering from polycystic ovary syndrome are more at risk of developing negative effects. An increase in the size of the ovariesis possible sometimes on the background of therapy.
Relatively rare, patients complain of such adverse effects, as insomnia, headaches, nervousness,nausea, vomiting, depression, weight gain and pain in the mammary glands.
Visual impairment is possible under the action of Clomid. This can be manifested by an indistinct blurry vision of objects and flashes in front of the eyes. As a rule, visual disturbances are reversible.
Before a woman begins using Clomid, she is recommended to go through a pelvic examination and a series of tests to exclude other possible causes of infertility in the woman, as well as infertility in her partner.
If the size of the ovaries increases with the use of Clomid, therapy should be discontinued. When the size of the ovaries normalizes, treatment can be resumed.
The use of Clomid increases the risk of multiple pregnancies. It is recommended to regularly monitor liver functionduring the treatment period.