Celebrex is a selective non-steroidal anti-inflammatory drug (NSAID) with an analgesic activity. In analgesic therapy, Celebrex capsules are used, each of which can contain 50 mg, 100mg, 200 mgor 400 mg of the active ingredient Celecoxib.
Celebrex capsules are used for symptomatic first-line therapy of acute and chronic pain, caused by various joint lesions. They can also be prescribedto increase the pain sensitivity threshold for dysmenorrhea or postoperative pain.
The analgesic effect of Celebrex is associated not only with the local anti-inflammatory effect, but also with the influence on the activity of the enzymes, which play an important role in perception and formation of pain sensations.
The dosage of Celebrex is:
- To reduce the perception of pain in juvenile arthritis in children aged 2 years and more: 50-100 mg twice a day;
- To reduce the pain perception in arthritis or osteoarthritis: 100-200 mg 1-2 times a day;
- To reduce the perception of pain in ankylosing spondylitis: 200 mg per day for 6 weeks, then 400 mg on subsequent days;
- To reduce the pain perception in women with dysmenorrhea: 400 mg once on the first day of therapy, then 200 mg twice a day on subsequent days.
Adult patients can take Celebrex capsuleswhole. To ease the pain in children, you can pour the contents of the capsule into food or drinks.
Celebrex does not enter into pharmacokinetic and pharmacodynamic interactions with antiepileptic, hypoglycemic, antifungal or diuretic drugs.
A significant decrease in the effectiveness of the analgesic therapy is possible in the interaction of Celebrex with proton pump inhibitors. In the clinical trials conducted, the safety and efficacy of a combined use of Celebrex with other NSAIDs has not been evaluated.
Undesirable reactions to Celebrex are observed only in 1-2% of patients, taking this analgesic. Due to the high actionselectivity, Celebrex has the lowest risk of complications from the gastrointestinal tract among all NSAIDs.
The most frequent unwanted reactions of Celebrex arise from the nervous or cardiovascular systems: dizziness, swelling, insomnia, increased blood pressure or anxiety. However, the severity of all side effects of Celebrex is significantly lower than that of nonselective NSAIDs.
For the most effective and safe analgesic therapy with Celebrex, patients should follow the recommendations below:
- The analgesic is prescribed only when other NSAIDs – Paracetamol, Diclofenac and others – turn ineffective;
- People with hypertension and severe renal failure should useCelebrex with caution.
- In a risk of cardiovascular complications, the analgesic should be used in combination with low doses of Aspirin;
- Against the background of a long-lasting analgesic therapy with Celebrex, it is necessary to control the general (hemoglobin) and biochemical blood tests at least once every 3 months.